Fatal overdose may occur when benzodiazepines are combined with other depressants such as opiates, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
Addiction potential
extremely physically and psychologically addictive
Toxicity
low toxicity; potentially lethality increases significantly when mixed with depressants like alcohol or opioids
Tolerance
full tolerance within a couple of days of continuous use; baseline after 7-14 days
Dangerous interactions
Caution / uncertain
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.