1,3-Butanediol
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Collated from PsychonautWiki, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as DMT, Dimethyltryptamine, DmitriPW
1,3-Butanediol, not to be confused with 1,4-butanediol (a GHB prodrug), is a depressant substance and a prodrug for the ketone body beta-hydroxybutyrate (BHB). It occurs as a thick, colorless liquid or solid depending on storage temperature, and has a distinct bitter-sweet taste. It is used as a recreational intoxicant with effects comparable to alcohol, though much shorter in duration. The R enantiomer of 1,3-Butanediol is more active. The toxicity of 1,3-Butanediol in animals models is lower than that of alcohol, potentially owing to the formation of a less toxic aldehyde following dehydrogenation by alcohol dehydrogenase.[1]PW
Oral
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Sublingual
Route dataPsychonautWiki
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Pharmacokinetics
MetabolismPH
Butanediol is metabolized by the liver... beta-hydroxybutyric acid /a main metabolite/ is further metabolized in the tricarboxylic acid cycle to carbon dioxide, which accounts for about 90% of the dose administered. In other studies... in which rats were fed 1,3-butanediol for 3 to 7 weeks, it was found that the blood level of beta-hydroxybutyrate, was also higher than normal.
R- and S-1,3-butylene glycol are taken up by the isolated liver of fed or starved rats at the same rate. R-1,3-butylene glycol is mainly transformed to the physiological ketone bodies R-3-hydroxybutyrate and acetoacetate. Only 29-38&% of the S-enantiomer are converted into physiological ketone bodies. The S-enantiomer is further metabolised to S-3-hydroxybutyrate (not a natural compound), lipids and carbon dioxide. Based on these results it can be concluded that the test item is metabolised via physiological pathways, suggesting that it has a low potential to accumulate.
External links
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.