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3-MeO-PCE

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Dose
Duration

3 sources

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Collated from PsychonautWiki, TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.

Sections
DissociativeArylcyclohexylaminesResearch-chemicalHabit-formingTentativePW

Also known as 3-MeO-PCE, Methoxyeticyclidine, methoxyieticyclidinePW

3-MeO-PCE may have a higher risk of causing mania, delusions, and psychosis than other dissociatives. It is strongly discouraged to take this substance in high dosages, for multiple days in a row, or in combination with other substances known to increase the risk of psychosis. Please see this section for more details.PW

Addiction potentialPW
highly addictive with a high potential for adverse side effects such as psychosis
ToxicityPW
toxic dosage is unknown
TolerancePW
full tolerance with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerancePW
dissociatives

Insufflated

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
1 mg3–6 mg6–12 mg12–20 mg20 mg+
025 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset3–15 minutes
Come-up45–90 minutes
Peak1.5–2 hours
Offset45–60 minutes
Total3–5 hours
After-effects4–48 hours
OnsetCome-upPeakOffset

Oral

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
2 mg4–8 mg8–15 mg15–25 mg25 mg+
031.25 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset30–90 minutes
Come-up1–2 hours
Peak2–3 hours
Offset1–2 hours
Total4–8 hours
After-effects4–48 hours
OnsetCome-upPeakOffset

Dangerous interactionsPW

StimulantsDepressants

🧬 Receptor activityPH

TargetActionAffinitySource
Diacylglycerol O-acyltransferase 1—Ki 1.34 nMCHEMBL
Unchecked—Ki 1.34 nMCHEMBL
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Plan when to take 3-MeO-PCE — see where onset, peak and comedown land on the clock

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.