← hubDrugs

4-AcO-DMT

Discover related
Class
Dose
Duration

3 sources

← All substances
🔗 MergedComparePsychonautWikiTripSitPharmacology

Collated from PsychonautWiki, TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.

Sections
PsychedelicSubstituted tryptaminesResearch-chemicalCommonPW

Also known as 4-AcO-DMT, 4-Acetoxy-DMT, Psilacetin, O-Acetylpsilocin, Synthetic mushrooms, 4-acoPW

A prodrug for Psilocin with extremely similar effects as Mushrooms.TS

Addiction potentialPW
non-addictive with low potential for abuse
ToxicityPW
toxic dose is unknown
TolerancePW
full tolerance almost immediately after ingestion; baseline after 7 days
Cross-tolerancePW
psychedelic

Insufflated

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
5 mg10–15 mg15–25 mg25–50 mg50 mg+
062.5 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset5–25 minutes
Come-up30–60 minutes
Peak1.5–2.5 hours
Offset1–1.5 hours
Total3–5 hours
After-effects2 hours
OnsetCome-upPeakOffset

Oral

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
5 mg7.5–15 mg15–25 mg25–45 mg45 mg+
056.25 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset15–40 minutes
Come-up30–75 minutes
Peak2–3.5 hours
Offset1–2 hours
Total4–7 hours
After-effects4–48 hours
OnsetCome-upPeakOffset

Dangerous interactionsPW

Lithium

Unsafe interactionsPW

Tramadol

Caution / uncertainPW

CannabisStimulants

🧬 Receptor activityPH

TargetActionAffinitySource
Mu-type opioid receptor—Ki 0.092 nMCHEMBL
Delta-type opioid receptor—Ki 80.8 nMCHEMBL
Kappa-type opioid receptor—Ki 998 nMCHEMBL
‹ PrevPage 1 / 11–3 of 3Next ›
Plan when to take 4-AcO-DMT — see where onset, peak and comedown land on the clock

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.