4-AcO-MET
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3 sources
Collated from PsychonautWiki, TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as 4-AcO-MET, 4-Acetoxy-MET, Metacetin, O-AcetylmetocinPW
A rare psychedelic tryptamine which is thought to be metabolised into 4-HO-MET. Onset and duration, intensity will vary but effect profile is largely the same.TS
Addiction potentialPW
not habit-forming
ToxicityPW
toxic dose is unknown
TolerancePW
full tolerance almost immediately after ingestion; half after 3 days; baseline after 7 days
Cross-tolerancePW
psychedelic
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 5 mg | 10–20 mg | 20–30 mg | 30–50 mg | 50 mg+ |
062.5 mg
LightCommonStrongHeavy
| Onset | 20–60 minutes |
|---|---|
| Come-up | 30–60 minutes |
| Peak | 1–2 hours |
| Offset | 2 hours |
| Total | 4–6 hours |
| After-effects | 2–4 hours |
OnsetCome-upPeakOffset
Dangerous interactionsPW
Unsafe interactionsPW
Caution / uncertainPW
🧬 Receptor activityPH
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| Solute carrier family 15 member 2 | — | Ki 17000 nM | CHEMBL | TargetSolute carrier family 15 member 2 Action— AffinityKi 17000 nM SourceCHEMBL |
| Solute carrier family 15 member 1 | — | Ki 150000 nM | CHEMBL | TargetSolute carrier family 15 member 1 Action— AffinityKi 150000 nM SourceCHEMBL |
Plan when to take 4-AcO-MET — see where onset, peak and comedown land on the clock
Plan a dose of 4-AcO-MET
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Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.