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4-HO-DET

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4 sources

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🔗 MergedComparePsychonautWikiTripSitPharmacologyTiHKAL

Collated from PsychonautWiki, TripSit, Pharmacology, TiHKAL. Where sources differ (e.g. dosing), Compare shows them side by side.

Sections
PsychedelicSubstituted tryptaminesResearch-chemicalPW

Also known as 4-HO-DET, Ethocin, CZ-74, 4-hydroxy-det, 4-INDOLOL, 3-[2-(DIETHYLAMINO)ETHYL], N,N-DIETHYL-4-HYDROXYTRYPTAMINE, 3-[2-(DIETHYLAMINO)ETHYL]-4-INDOLOL, 4-HO-DET PHOSPHATE ESTERPW

A rare compound first produced by Albert Hoffman, also known as ethocin. Structurally related to 4-HO-MET (metocin) and psilocin (4-HO-DMT), this drug has similar psychedelic effects but little recorded human usage. Probably similar to mushrooms. Potentially stimulating.TS

Addiction potentialPW
not habit-forming
ToxicityPW
toxic dose is unknown
TolerancePW
full tolerance almost immediately after ingestion; half after 3 days; baseline after 7 days
Cross-tolerancePW
psychedelic

Oral

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
5 mg10–15 mg20–30 mg30–45 mg45 mg+
056.25 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset20–45 minutes
Come-up30–60 minutes
Peak2.5–3.5 hours
Offset1.5–2 hours
Total5–7 hours
After-effects1–4 hours
OnsetCome-upPeakOffset

Dangerous interactionsPW

Lithium

Unsafe interactionsPW

Tramadol

Caution / uncertainPW

CannabisStimulants

🧬 Receptor activityPH

TargetActionAffinitySource
Sodium/potassium-transporting ATPase subunit alpha-2/beta-3—Ki 14.4 nMCHEMBL
Sodium/potassium-transporting ATPase subunit alpha-2/beta-2—Ki 16.4 nMCHEMBL
Sodium/potassium-transporting ATPase subunit alpha-2/beta-1—Ki 23.2 nMCHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1/beta-1—Ki 138 nMCHEMBL
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Plan when to take 4-HO-DET — see where onset, peak and comedown land on the clock

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.