5-MeO-DMT
Discover related
3 sources
Collated from PsychonautWiki, TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as 5-MeO-DMT, The God Molecule, Toad, Jaguar, toads, 5-meo, 5-medmtPW
WARNING: 5-MeO-DMT is not a valid substitute for DMT. Despite what their names might suggest, 5-MeO-DMT and DMT have distinct effects and risk profiles and should be regarded as completely separate entities. Please see this this section for more information.PW
Insufflated
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 3 mg | 5–8 mg | 8–15 mg | 15–25 mg | —+ |
| Onset | 1–10 minutes |
|---|---|
| Peak | 10–40 minutes |
| Offset | 30–60 minutes |
| Total | 2–3 hours |
| After-effects | 1–3 hours |
Smoked
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 1 mg | 3–6 mg | 6–12 mg | 12–20 mg | 20 mg+ |
| Onset | 5–60 seconds |
|---|---|
| Come-up | 30–60 seconds |
| Peak | 5–15 minutes |
| Offset | 10–20 minutes |
| Total | 20–40 minutes |
| After-effects | 15–60 minutes |
Unsafe interactionsPW
🧬 Receptor activityPH
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | — | Ki 5.495 nM | CHEMBL | Target5-hydroxytryptamine receptor 1A Action— AffinityKi 5.495 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 6 | — | Ki 13 nM | CHEMBL | Target5-hydroxytryptamine receptor 6 Action— AffinityKi 13 nM SourceCHEMBL |
| Serotonin 2 (5-HT2) receptor | — | Ki 15 nM | CHEMBL | TargetSerotonin 2 (5-HT2) receptor Action— AffinityKi 15 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2A | — | Ki 15 nM | CHEMBL | Target5-hydroxytryptamine receptor 2A Action— AffinityKi 15 nM SourceCHEMBL |
| Melatonin receptor type 1B | — | Ki 16 nM | CHEMBL | TargetMelatonin receptor type 1B Action— AffinityKi 16 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1D | — | Ki 20 nM | CHEMBL | Target5-hydroxytryptamine receptor 1D Action— AffinityKi 20 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 7 | — | Ki 30 nM | CHEMBL | Target5-hydroxytryptamine receptor 7 Action— AffinityKi 30 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2C | — | Ki 42 nM | CHEMBL | Target5-hydroxytryptamine receptor 2C Action— AffinityKi 42 nM SourceCHEMBL |
| Serotonin 1 (5-HT1) receptor | — | Ki 50 nM | CHEMBL | TargetSerotonin 1 (5-HT1) receptor Action— AffinityKi 50 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2B | — | Ki 52 nM | CHEMBL | Target5-hydroxytryptamine receptor 2B Action— AffinityKi 52 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1B | — | Ki 90 nM | CHEMBL | Target5-hydroxytryptamine receptor 1B Action— AffinityKi 90 nM SourceCHEMBL |
| Melatonin receptor type 1A | — | Ki 210 nM | CHEMBL | TargetMelatonin receptor type 1A Action— AffinityKi 210 nM SourceCHEMBL |
Pharmacokinetics
MetabolismPH
N,n-dimethyl-5-methoxytryptamine has known human metabolites that include Bufotenine.
Plan a dose of 5-MeO-DMT
Loading the fact-sheet…
Logging a dose needs somewhere to keep it. Start a free session — no signup; it and everything in it expire in 7 days.
External links
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.