Adinazolam
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Collated from TripSit, Pharmacology, DrugCentral. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as deracynTS
Benzodiazepine derivative that has some antidepressant properties. Never FDA approved, yet however has been sold as a research chemical.TS
Oral
Route dataTripSit
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| — | 5–15 mg | 15–30 mg | 30–50 mg | —+ |
| Onset | 10–25 minutes |
|---|---|
| Total | 2–5 hours |
| After-effects | 1–16 hours |
🧬 Receptor activityDC
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| GABA-A receptor (GABRD) | Positive allosteric modulator | — | DRUGCENTRAL | TargetGABA-A receptor (GABRD) ActionPositive allosteric modulator Affinity— SourceDRUGCENTRAL |
| Translocator protein (TSPO) | — | 7.1 IC50 | DRUGCENTRAL | TargetTranslocator protein (TSPO) Action— Affinity7.1 IC50 SourceDRUGCENTRAL |
Mechanism of actionPH
Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
PharmacodynamicsPH
Adinazolam is a benzodiazepine derivative used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia. Adinazolam binds with high affinity to the GABA benzodiazepine receptor complex. Considerable evidence suggest that the central pharmacologic/therapeutic actions of alprazolam are mediated via interaction with this receptor complex.
Pharmacokinetics
Half-lifePH
Less than 3 hours.
MetabolismPH
The drug primarily undergoes hepatic metabolism to form the main metabolite N-desmethyladinazolam, alpha-hydroxyalprazolam, and estazolam.
Adinazolam has known human metabolites that include N-demethyladinazolam.
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