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| TripSit | Pharmacology | ||
|---|---|---|---|
| Classification | |||
| Class / category | — | ||
| Also known as | acetylsalicylate | — | |
| Safety | |||
| Dose · Oral | |||
| Threshold | 50 mg | — | |
| Heavy | 1.6 mg+ | — | |
| Duration | |||
| Onset | 30–90 minutes | — | |
| Pharmacology | |||
| Receptor activity | — | Nicotinate phosphoribosyltransferaseProstaglandin G/H synthase 1Prostaglandin G/H synthase 2Carbonic anhydrase 2Carbonic anhydrase 7Carbonic anhydrase 9Carbonic anhydrase 12Carbonic anhydrase 1Carbonic anhydrase 4Solute carrier family 22 member 20Fatty acid-binding protein, liverSolute carrier family 22 member 6Unchecked | |
| Half-life | — | The half-life of ASA in the circulation ranges from 13 - 19 minutes. Blood concentrations drop rapidly after complete absorption. The half-life of the salicylate ranges between 3.5 and 4.5 hours. 15 to 20 minutes (for intact molecule); rapidly hydrolyzed to salicylate. In breast milk (as salicylate): 3.8 to 12.5 hours (average 7.1 hours) following a single 650 mg dose of aspirin. Cats are deficient in glucuronyl transferase and have a prolonged excretion of aspirin (the half-life in cats is 37.5 hr). | |
| Protein binding | — | 50% to 90% of a normal therapeutic concentration salicylate (a main metabolite of acetylsalicylic acid) binds plasma proteins, particularly albumin, while acetylsalicylic acid itself binds negligibly. Acetylsalicylic acid has the ability to bind to and acetylate many proteins, hormones, DNA, platelets, and hemoglobin. | |
TripSit summary
A widely used anti-inflammatory and blood-thinner produced by acetylation of the naturally occurring salicyclic acid. Part of the nonsteroidal antiinflammatory class of drugs, a cyclooxygenase inhibitor. Very common over-the-counter pain reliever and fever reducer. Also used in smaller doses to lower risk of heart attack.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.