How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
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| TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | — | ||
| Also known as | strattera | — | — | — | |
| Safety | |||||
| Dose · Oral | |||||
| Light | 10–18 mg | — | — | — | |
| Common | 18–40 mg | — | — | — | |
| Strong | 40–80 mg | — | — | — | |
| Duration | |||||
| Onset | 15–45 minutes | — | — | — | |
| Total | 8–12 hours | — | — | — | |
| After-effects | 2–24 hours | — | — | — | |
| Pharmacology | |||||
| Receptor activity | — | Rattus norvegicus | SLC6A2CYP2D6KCNJ6KCNJ5KLF10KCNH2SLC6A3SLC6A4 | — | ≠ |
| Half-life | — | The reported half-life depends on the CYP2D6 genetic polymorphisms of the individual and can range from 3 to 5.6 hours. The plasma elimination half life in normal (extensive) metabolizers is about 5 hours. In person who are poor metabolizers (7% of whites and 2% of blacks), the drug plasma levels are much higher and the plasma elimination half life is 24 hours. Mean apparent plasma clearance of atomoxetine after oral administration in adult extensive metabolizers (EMs) is 0.35 L/hr/kg and the mean half-life is 5.2 hours. Following oral administration of atomoxetine to poor metabolizers (PMs), mean apparent plasma clearance is 0.03 L/hr/kg and mean half-life is 21.6 hours. For PMs, AUC of atomoxetine is approximately 10-fold and Css, max is about 5-fold greater than EMs. The elimination half-life of 4-hydroxyatomoxetine is similar to that of N-desmethylatomoxetine (6 to 8 hours) in EM subjects, while the half-life of N-desmethylatomoxetine is much longer in PM subjects (34 to 40 hours). ... In extensive metabolizers, atomoxetine has a plasma half-life of 5.2 hours, while in poor metabolizers, atomoxetine has a plasma half-life of 21.6 hours. ... ... Twenty-one cytochrome P450 2D6 extensive metabolizer patients participated in these single-dose and steady-state pharmacokinetic evaluations. Atomoxetine was rapidly absorbed, with peak plasma concentrations occurring 1 to 2 hours after dosing. Half-life averaged 3.12 and 3.28 hours after a single dose and at steady state, respectively. ... | — | — | |
| Protein binding | — | At therapeutic concentrations, 98.7% of plasma atomoxetine is bound to protein, with 97.5% of that being bound to albumin, followed by alpha-1-acid glycoprotein and immunoglobulin G. | — | — | |
TripSit summary
A NRI that is used for ADHD. With a quite odd pharmacological background.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.