Butyrfentanyl
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Mechanism of action
Butyrfentanyl is a µ opioid receptor agonist similar to fentanyl.
Pharmacodynamics
Data for the pharmacodynamics of butyrfentanyl are not readily available.
Pharmacokinetics
Half-life
Data for the half life of butyrfentanyl are not readily available.
Absorption
Data for the absorption of butyrfentanyl are not readily available.
The route of elimination of butyrfentanyl has not been well described in the literature but most opioids are mainly eliminated in the urine.
Data for the volume of distribution of butyrfentanyl are not readily available.
Data for the clearance of butyrfentanyl are not readily available.
Metabolism
Butyrfentanyl can be N-dealkylated to nor-butyrfentanyl by CYP3A4 and CYP2D6, hydroxylated to (ω-1)-hydroxy-butyrfentanyl by CYP3A4, 4'-hydroxylated to 4'-hydroxy-butyrfentanyl, hydroxylated to ω-hydroxy-butyrfentanyl bye CYP2D6 or CYP3A4, or hydroxylated to β-hydroxy-butyrfentanyl by CYP3A4. ω-hydroxy-butyrfentanyl is further metabolized to ω-carboxy-butyrfentanyl while 4'-hydroxy-butyrfentanyl is further metabolized to 4'-hydroxy-3'-methoxy-butyrfentanyl. Many of these metabolites may undergo further conjugation reactions with glucuronic acid or sulfate.
Protein binding
Protein binding studies for butyrfentanyl have not been performed but due to its structural similarity with fentanyl it is likely highly bound to serum albumin and alpha-1-acid glycoprotein in circulation.
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