Cannabidiol
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| PsychonautWiki | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | — | ||
| Also known as | CannabidiolCBDEpidiolex | — | — | — | |
| Safety | |||||
| Addiction potential | low abuse potential | — | — | — | |
| Toxicity | well-tolerated and shows little to no toxicity | — | — | — | |
| Dose · Oral | |||||
| Threshold | 2 mg | — | — | — | |
| Light | 5–15 mg | — | — | — | |
| Common | 15–30 mg | — | — | — | |
| Strong | 30–60 mg | — | — | — | |
| Heavy | 60 mg+ | — | — | — | |
| Duration | |||||
| Total | 1.5–4 hours | — | — | — | |
| Pharmacology | |||||
| Receptor activity | — | D(2) dopamine receptorCytochrome P450 1A1Cannabinoid receptor 1Cytochrome P450 3A5Cannabinoid receptor 2Equilibrative nucleoside transporter 1Cytochrome P450 2B6Cytochrome P450 2C19Cytochrome P450 3A45-hydroxytryptamine receptor 2CMu-type opioid receptorKappa-type opioid receptorCytochrome P450 2D6Cytochrome P450 1A2D(1A) dopamine receptorHistamine H3 receptorAlpha-2B adrenergic receptorSigma intracellular receptor 2Cytochrome P450 1B1Alpha-2C adrenergic receptorCytochrome P450 2C9Delta-type opioid receptorCytochrome P450 3A7Cytochrome P450 2C11L-lactate dehydrogenase A chainCytochrome P450 2A6Steroid 17-alpha-hydroxylase/17,20 lyase | GPR55GPR18TRPV1Trpv2CNR1CNR2Faah | — | ≠ |
| Half-life | — | The CBD component of sublingual Sativex was found to have a half life (t1/2) of 1.44hr, while buccal Sativex was found to have a half life (t1/2) of 1.81hr. | — | — | |
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.