Chloral hydrate
Discover related
2 sources
How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
Show:
| TripSit | Pharmacology | ||
|---|---|---|---|
| Classification | |||
| Class / category | — | ||
| Also known as | chloral-hydrateaquachloralsomnos | — | |
| Safety | |||
| Dose · Oral | |||
| Common | 200–500 mg | — | |
| Strong | 500–1000 mg | — | |
| Duration | |||
| Onset | 20–60 minutes | — | |
| Total | 5–10 hours | — | |
| After-effects | 2–6 hours | — | |
| Pharmacology | |||
| Half-life | — | The plasma half-life of trichloroethanol, the active metabolite, is about 7 to 10 hours. The average half-life of trichloroethanol glucuronide was 6.7 hr. The average plasma half-life for chloral hydrate metabolites was 8.2 hr; the half-life of the third chloral hydrate metabolite, trichloroacetic acid, was about four days, as it binds extensively to plasma proteins. The plasma half-life for therapeutic doses of chloral hydrate is 4 to 5 min, whereas for trichloroethanol /a metabolite/ is 8 to 12 hr and for trichloroacetic acid /a metabolite/, 67 hr. This study was designed to characterize the kinetics of chloral hydrate (CH) metabolism, and the formation and elimination of trichloroacetate (TCA), dichloroacetate (DCA), trichloroethanol (TCOH), and trichloroethanol glucuronide (TCOG) in male B6C3F1 mice. Mice were dosed with 67.8, 678, and 2034 umol/kg of CH through the tail vein. ... After intravenous administration, CH rapidly disappeared from blood with a terminal half-life ranging from 5 to 24 min. ... The terminal half-lives of TCOH and TCOG were similar, ranging from 0.2 to 0.7 hr. ... | |
TripSit summary
Chloral Hydrate, a sedative drug discovered in 1832 with a history of recreational use going back to the 19th century. Sometimes prescribed for extreme insomnia. For such an old drug, relatively little is known about its long-term term effects on the body. Produces intoxication comparable to alcohol or benzodiazepines.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.