Chloroform
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| TripSit | Pharmacology | ||
|---|---|---|---|
| Classification | |||
| Class / category | — | ||
| Safety | |||
| Duration | |||
| After-effects | 1–6 hours | — | |
| Pharmacology | |||
| Half-life | — | Whole body: 1.5 hours; [TDR, p. 318] After inhalation of approximately 5 mg (38)Cl-chloroform, about 80% of the chloroform was found to have been absorbed ... . Eight volunteers expired 18 to 67% of an oral dose of 500 mg (13)C-chloroform (in capsules of olive oil) unchanged; in two subjects, about half of the dose was eliminated in the expired air as (13)CO2. The decline in the concentration of chloroform in blood was described by a two-compartment model, with initial and second-phase half-lives of 14 and 90 min, respectively, averaged over four subjects. In humans given a single oral dose of 0.5 g chloroform, about 50-52% of the dose was absorbed, and virtually all of the absorbed dose was metabolized to carbon dioxide. Blood levels peaked after 1.5 hr and declined in line with a two-compartment model with half-lives of 13 and 90 min, respectively ... | |
TripSit summary
A naturally occurring organic compound once used as an anaesthetic. Has practically disappeared in this usage due to numerous harmful effects including danger of sudden death through cardiac arrhythmia. Has been implicated in numerous murders. Highly unsafe.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.