Clonidine
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| PsychonautWiki | TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|---|
| Classification | ||||||
| Class / category | — | — | — | ≈ | ||
| Also known as | CatapresCatapres-TTSKapvayNexiclon XR | catapreskapvayduraclon | — | — | — | ≈ |
| Safety | ||||||
| Addiction potential | not addictive and has a low potential for abuse | — | — | — | — | |
| Dangerous interactions | — | — | — | — | ||
| Dose · Oral | ||||||
| Threshold | 25 μg | — | — | — | — | |
| Light | 50–75 μg | 25–50 µg | — | — | — | ≠ |
| Common | 75–100 μg | 50–100 µg | — | — | — | ≠ |
| Strong | 100–300 μg | 100–250 µg | — | — | — | ≠ |
| Heavy | 300 μg+ | — | — | — | — | |
| Duration | ||||||
| Onset | 15–45 minutes | 15–45 minutes | — | — | — | = |
| Total | 6–8 hours | 8–16 hours | — | — | — | ≠ |
| After-effects | — | 1–4 hours | — | — | — | |
| Pharmacology | ||||||
| Receptor activity | — | — | Alpha-2A adrenergic receptorAlpha-2B adrenergic receptorAlpha-2C adrenergic receptorAlpha-1A adrenergic receptor5-hydroxytryptamine receptor 7Alpha-1D adrenergic receptorAlpha-1B adrenergic receptorSigma intracellular receptor 25-hydroxytryptamine receptor 2C5-hydroxytryptamine receptor 2A | Adra1dADRA2AADRA2BADRA2CHcn1Hcn2Hcn4HTR1AADRA1AADRA1BADRB1SLC47A1NISCHSLC22A1SLC22A2 | — | ≠ |
| Half-life | — | — | The elimination half life after epidural administration is 30 minutes but otherwise can range from 6-23h. The elimination half-life of the drug ranges from 6 to 24 hours, with a mean of about 12 hours. THE PHARMACOKINETICS OF CLONIDINE WERE INVESTIGATED IN HEALTHY VOLUNTEERS OVER A TIME MORE THAN 3 TIMES LONGER THAN PREVIOUSLY REPORTED. THE COMPLETE BIOAVAILABILITY OF CLONIDINE AND ITS ELIMINATION T/2 (20 TO 25.5 HOURS) REMAINED CONSTANT AFTER SINGLE AND MULTIPLE DOSES. The plasma half-life of clonidine is 6-20 hours in patients with normal renal function. The half-life in patients with impaired renal function has been reported to range from 18-41 hours. The elimination half-life of the drug may be dose dependent, increasing with increasing dose. | — | — | |
| Protein binding | — | — | Clonidine is 20-40% bound to plasma proteins, especially albumin. | — | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
PsychonautWiki oral
TripSit Oral
0375 μg
LightCommonStrongHeavy
Duration at a glance
Total duration on one shared scale.
PsychonautWiki
TripSit
TripSit summary
Is a medication that is used to treat high blood pressure, anxiety, withdrawal (Typically from Alcohol, Opioids, Smoking) and many other uses.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.