Codeine
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| PsychonautWiki | TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | ≈ | ||
| Also known as | CodeineLeanPurple DrankSyrup | — | — | — | |
| Safety | |||||
| Addiction potential | moderately addictive with a high potential for abuse | — | — | — | |
| Toxicity | low toxicitypotentially lethal when mixed with depressants like alcohol or benzodiazepines | — | — | — | |
| Dangerous interactions | — | — | — | ||
| Dose · Oral | |||||
| Threshold | 30 mg | — | — | — | |
| Light | 50–100 mg | 50–100 mg | — | — | = |
| Common | 100–150 mg | 100–150 mg | — | — | = |
| Strong | 150–200 mg | — | — | — | |
| Heavy | 200 mg+ | 150 mg+ | — | — | ≠ |
| Duration | |||||
| Onset | 30–45 minutes | 30–45 minutes | — | — | = |
| Total | 3–6 hours | 3–6 hours | — | — | = |
| After-effects | — | 1–12 hours | — | — | |
| Pharmacology | |||||
| Receptor activity | — | — | — | OPRD1OPRK1OPRM1 | |
| Half-life | — | — | Plasma half-lives of codeine and its metabolites have been reported to be approximately 3 hours. Radioimmunoassay (RIA) was used to determine several pharmacokinetic parameters of codeine in man, including the relative bioavailability after oral and intramuscular administration. The study followed a crossover design in 6 healthy, young (18 to 21 yr), male volunteers. Three subjects received 65 mg codeine phosphate orally in an analgesic mixture which also contained aspirin, phenacetin, and caffeine. At the same time a similar group received an equivalent dose of codeine phosphate in a single intramuscular injection. Two weeks later the study was repeated so that each group received the alternate treatment. Plasma samples were collected at various times after drug administration, and codeine concentrations were determined by a specific RIA procedure. The procedure can detect less than 50 pg of codeine. Following intramuscular administration, peak plasma concentrations (194 to 340 ng/ml) were observed between 0.25 to 1 hr; after oral dosing, peak codeine plasma concentrations (102 to 140 ng/ml) appeared within 0.75 to 1 hr. The mean plasma t1/2 and volume of distribution of codeine following intramuscular injection were 3.32 hr and 5.1 L/kg, respectively. Oral, relative to intramuscular, bioavailability of codeine, based on areas under the codeine plasma curves, was 42% to 71% (mean, 53%). Assuming a rate of hair growth of 1 cm/month, the mean hair elimination half-life of /codeine was 0.61 months (95% CI, 0.54-0.69)/ ... . The elimination half-life of codeine is 2.5 to 3.5 hours with a clinical duration of 4 to 8 hours because of active metabolites. Codeine is metabolized rapidly by the tissues of humans, dogs, & rats. Metabolic alteration followed by rapid urinary excretion begins a few minutes after im injection & after a slight delay following oral admin. About one-half an ordinary dose is eliminated within 6 hr & all within 24 hr. | — | |
| Protein binding | — | — | 7-25% bound to plasma proteins. | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
Duration at a glance
Total duration on one shared scale.
PsychonautWiki summary
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
TripSit summary
Codeine is a weaker opioid used to treat mild to moderate pain and to relieve cough. In many countries it is available over the counter in combination with paracetamol, which can easily be extracted to retrieve near-pure codeine. For this reason, it is used widely as a recreational opioid. It is metabolised into morphine in the body at a rate of 5% mg for mg.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.