Cyclizine
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| TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|
| Classification | ||||
| Class / category | — | — | ||
| Safety | ||||
| Dose · Oral | ||||
| Common | 25–50 mg | — | — | |
| Duration | ||||
| Onset | 10–30 minutes | — | — | |
| After-effects | 14 hours | — | — | |
| Pharmacology | ||||
| Receptor activity | — | H1 receptorHistamine H1 receptor5-hydroxytryptamine receptor 2AMuscarinic acetylcholine receptor M4Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M15-hydroxytryptamine receptor 2BMuscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M55-hydroxytryptamine receptor 2CAlpha-2A adrenergic receptorAlpha-1D adrenergic receptorSodium-dependent dopamine transporterD(3) dopamine receptorAlpha-1B adrenergic receptorUnchecked | HRH1HTR2AHTR2BHTR2CAdra1bADRA1DADRA2AMAOBCYP2D6DRD3CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A3 | ≠ |
| Half-life | — | 20 hours | — | |
TripSit summary
First generation antihistamine and anticholinergic drug used to combat nausea and vomiting. Causes drowsiness. Like most antihistamines in high doses it induces delirium and vivid realistic hallucinations. Probably uncomfortable and not enjoyable.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.