Desomorphine
3 sources
Collated from PsychonautWiki, Pharmacology, DrugCentral. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as Desomorphine, Krokodil, KrokPW
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.PW
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 10 mg | 10–15 mg | 15–20 mg | 20–30 mg | 30 mg+ |
| Total | 3–4 hours |
|---|
🧬 Receptor activityDC
Mechanism of actionPH
Morphine, codeine, dilaudid, and desomorphine inhibit the activity of cholinesterase from the following sources: human, dog or rabbit serum, and human or rabbit brain. The degree of inhibition varies with the source of the enzyme, which might account for the selective action of these drugs on physiological systems. The inhibition is in part competitive and in part non-competitive, judging by the relative reaction velocity at different substrate concentrations. The affinity of the alkaloids for the enzyme in human serum is as great (dilaudid) or greater (codeine, morphine and desomorphine) than the affinity of the enzyme for acetylcholine.
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Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.