3 sources
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| TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|
| Classification | ||||
| Class / category | — | — | ||
| Also known as | dimenhydrinategravol | — | — | |
| Safety | ||||
| Dose · Oral | ||||
| Light | 100–250 mg | — | — | |
| Duration | ||||
| Onset | 30–90 minutes | — | — | |
| Total | 5–8 hours | — | — | |
| Pharmacology | ||||
| Receptor activity | — | Histamine H1 receptorMuscarinic acetylcholine receptor M4Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M25-hydroxytryptamine receptor 2AMuscarinic acetylcholine receptor M55-hydroxytryptamine receptor 2CSigma non-opioid intracellular receptor 15-hydroxytryptamine receptor 2BAlpha-1D adrenergic receptorAlpha-2A adrenergic receptorSodium-dependent dopamine transporterSodium-dependent noradrenaline transporterAlpha-2B adrenergic receptorUnchecked | HRH1HTR2AHTR2BHTR2CADRA1DADRA2AADRA2BCYP2D6CHRM1CHRM2CHRM3CHRM4CHRM5SIGMAR1SLC6A3SLC6A2 | ≠ |
| Half-life | — | The plasma elimination half life of dimenhydrinate is 5-8 hours. | — | |
| Protein binding | — | Dimenhydrinate is 70-85% protein bound in plasma. | — | |
TripSit summary
A combination of diphenhydramine and a mild stimulant to counteract the drowsiness accompanied by typical medical use of diphenhydramine. Roughly half the potency of DPH. Small doses can relieve motion sickness, reduce body load from opioids or DXM. Becomes a deliriant in high doses, keeping the user awake and often causing dysphoric, realistic hallucinations.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.