Ethchlorvynol
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| TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|
| Classification | ||||
| Class / category | — | — | ||
| Also known as | placidylethchlorvnol | — | — | |
| Safety | ||||
| Dose · Oral | ||||
| Light | 100–200 mg | — | — | |
| Common | 200–500 mg | — | — | |
| Strong | 500–750 mg | — | — | |
| Duration | ||||
| Onset | 15–45 minutes | — | — | |
| Total | 6–9 hours | — | — | |
| After-effects | 1–6 hours | — | — | |
| Pharmacology | ||||
| Receptor activity | — | — | GABRA1 | |
| Half-life | — | Plasma half-life is approximately 10 to 20 hours, terminal half-life is 21-100 hours. AFTER EQUILIBRIUM FOLLOWING HYPNOTIC DOSES, BLOOD LEVEL FALLS RAPIDLY, WITH AVG T/2 OF 5.6 HR. ... HALF-LIFE FOR ... DISTRIBUTION ... 5 TO 6 HR ... HALF-LIFE FOR ... ELIMINATION /IS/ 70 HR /HUMAN/ Plasma half-life is approximately 10 to 20 hours. 100 hr (overdose) /From table/ A 33 year old obese, hypothyroid, white male with several medical problems was admitted to University Hospital in September 1984 for treatment of drug intoxication. Admitting medications included ethchlorvynol in addition to other central nervous system depressants. Initial serum concn were reported at 70 ug/ml in this somnolent yet totally conscious adult. Established therapeutic concn are 2-8 ug/ml, with toxic exceeding 20 ug/ml. A tolerance phenomenon seemed evident. Serum ethchlorvynol concn were monitored daily during early hospitalization and continued to be substantially greater than reported toxic concn. Kinetic values were as follows: total body clearance 9.92 ml/min, volume of distribution 68.0 liters, and half-life 78 hr. These values are unique in that they were calculated from a patient who had not suffered an acute overdose, thereby differing markedly from previously published values. The influence of hypothyroidism and hyperlipidemia on these markedly different values appears to be significant. Ethchlorvynol should probably be added to the list of drugs influenced by thyroid disease. | — | |
| Protein binding | — | 35-50% | — | |
TripSit summary
Sedative Hypnotic medication made in the 50's. It was used for short term help for insomnia (No longer than two weeks)
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