Gabapentin
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| PsychonautWiki | TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|---|
| Classification | ||||||
| Class / category | — | — | — | ≈ | ||
| Also known as | GabapentinNeurontinGabaroneGralise | neurontin | — | — | — | ≈ |
| Safety | ||||||
| Toxicity | low toxicity | — | — | — | — | |
| Dangerous interactions | — | — | — | — | ||
| Dose · Oral | ||||||
| Threshold | 200 mg | — | — | — | — | |
| Light | 200–900 mg | 300–600 mg | — | — | — | ≠ |
| Common | 900–1500 mg | 600–900 mg | — | — | — | ≠ |
| Strong | 1500–2400 mg | — | — | — | — | |
| Heavy | 2400 mg+ | — | — | — | — | |
| Duration | ||||||
| Onset | 30–120 minutes | 30–90 minutes | — | — | — | ≠ |
| Total | 6–10 hours | 5–12 hours | — | — | — | ≠ |
| After-effects | — | 1–6 hours | — | — | — | |
| Pharmacology | ||||||
| Receptor activity | — | — | Voltage-dependent calcium channel subunit alpha-2/delta-1Unchecked | KCNQ3KCNQ5CACNA2D1CACNA2D2ADORA1ADRA2AGABBR2GRIN3ASLC7A5SCN5A | — | ≠ |
| Half-life | — | — | The elimination t<sub>1/2</sub> of gabapentin in patients with normal renal function is 5-7 hours. In patients with reduced renal function, the elimination t<sub>1/2</sub> may be prolonged - in patients with a creatinine clearance of <30 mL/min, the reported half-life of gabapentin was approximately 52 hours. In dogs ... elimination half life is approximately 2-4 hours. Gabapentin elimination half-life is 5 to 7 hours and is unaltered by dose or following multiple dosing. In cats ... elimination half life of 2.8 hours is similar to dogs. | — | — | |
| Protein binding | — | — | Less than 3% of an orally administered dose of gabapentin is bound to plasma proteins. | — | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
Duration at a glance
Total duration on one shared scale.
PsychonautWiki summary
Fatal overdose may occur when gabapentinoids are combined with other depressants such as opiates, benzodiazepines, barbiturates, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
TripSit summary
An analogue of GABA also known as Neurontin, originally developed to treat epilepsy. Commonly prescribed for neuropathic pain, it also has pronounced anxiolytic effects leading to its use in treating anxiety disorders.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.