Glutethimide
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| TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|
| Classification | ||||
| Class / category | — | — | ||
| Also known as | doridenelrodormnoxyronglimid | — | — | |
| Safety | ||||
| Duration | ||||
| Onset | 30–45 minutes | — | — | |
| Total | 2–8 hours | — | — | |
| After-effects | 1–12 hours | — | — | |
| Pharmacology | ||||
| Receptor activity | — | — | GABRA1 | |
| Half-life | — | 10-12 hours Half-life about 10 to 12 hours. The decline of serum concentrations of glutethimide is biphasic; the half-life for the first phase is about 4 hrs and the half-life for the second phase is 10-12 hours. The apparent serum half-life of the drug in patients severely intoxicated with glutethimide has been reported to be prolonged, but this may have been due to continued absorption of the drug. In a series of patients with glutethimide overdose, mean serum half-life has been found to be prolonged to around 40.1 hr. The definition of biologic half-life for glutethimide is somewhat difficult because of the rapidly appearing inactive metabolites (glucuronides). The half-life of the inactivated dose (effective biologic half-life) and the time when half of the dose is excreted (maximal biologic half-life) are different; the effective biologic half-life is approximately 10 hr, and the maximal biologic half-life is approximately 16 hr. The spontaneous decline of glutethimide blood levels follows a biphasic curve, with an initial rapid phase and a later slow phase. During the initial rapid phase, a mean serum half-life of 3.9 hr is obtained... The decline in drug concentration during the second, slower phase gives a mean serum half-life of 11.6 hr, this being brought about by loss of drug from tissue compartments and blood (or central compartment) through metabolism and excretion. | — | |
TripSit summary
Is a hypnotic sedative that was introduced in 1954, as a "safe" alternative to barbiturates to treat insomnia. Anecdotally long term use has had effects similar to withdrawal, while still on a stable dose of the drug.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.