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Halazepam

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3 sources

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Collated from TripSit, Pharmacology, DrugCentral. Where sources differ (e.g. dosing), Compare shows them side by side.

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BenzodiazepineHabit-formingDepressantTS

Also known as paxipamTS

A less common prescription benzodiazepine and derivative of Nordazepam. Also known as Paxipam, it is no longer prescribed in the USA. Sedating, hypnotic and anxiolytic. High doses may induce amnesia and lowered inhibitions.TS

Oral

Route dataTripSit

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
—10–20 mg20–40 mg40–80 mg—+
080 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset15–45 minutes
Total8–14 hours
After-effects12–40 hours
OnsetCome-upPeakOffset

🧬 Receptor activityDC

TargetActionAffinitySource
GABA-A receptor; anion channel (GABRP)Positive allosteric modulator—DRUGCENTRAL
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Mechanism of actionPH

Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

Pharmacokinetics

MetabolismPH

Hepatic.

Plan when to take Halazepam — see where onset, peak and comedown land on the clock

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.