Hexobarbital
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3 sources
Collated from TripSit, Pharmacology, DrugCentral. Where sources differ (e.g. dosing), Compare shows them side by side.
Is a barbiturate that was once used for inducing anesthesia for surgery. It has a very rapid onset, and a short duration of effects.TS
Oral
Route dataTripSit
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| — | 10–15 mg | 15–20 mg | 20–30 mg | —+ |
| Onset | 1–2 minutes |
|---|---|
| Total | 30–45 minutes |
| After-effects | 1–4 hours |
🧬 Receptor activityDC
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| GABA-A receptor alpha-1/beta-3/gamma-2 (GABRA1) | — | — | DRUGCENTRAL | TargetGABA-A receptor alpha-1/beta-3/gamma-2 (GABRA1) Action— Affinity— SourceDRUGCENTRAL |
| GABA-A receptor alpha-2/beta-3/gamma-2 (GABRG2) | — | — | DRUGCENTRAL | TargetGABA-A receptor alpha-2/beta-3/gamma-2 (GABRG2) Action— Affinity— SourceDRUGCENTRAL |
| GABA-A receptor alpha-3/beta-3/gamma-2 (GABRG2) | — | — | DRUGCENTRAL | TargetGABA-A receptor alpha-3/beta-3/gamma-2 (GABRG2) Action— Affinity— SourceDRUGCENTRAL |
| GABA-A receptor alpha-5/beta-3/gamma-2 (GABRG2) | — | — | DRUGCENTRAL | TargetGABA-A receptor alpha-5/beta-3/gamma-2 (GABRG2) Action— Affinity— SourceDRUGCENTRAL |
Mechanism of actionPH
Hexobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
PharmacodynamicsPH
Hexobarbital is a barbiturate derivative having hypnotic and sedative effects. It was subsequently used in the 1940s and 1950s as an anesthetic for surgery. Furthermore, the agent also demonstrates a fairly quick onset of action that also possesses a short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days.
Pharmacokinetics
MetabolismPH
Hepatic.
Protein bindingPH
25%
Plan a dose of Hexobarbital
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