Collated from TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as h-aTS
A compound that is extracted from the herbs of Huperziceae family. Is known as an acetylcholinesterase inhibitor, which stops an enzyme from breaking down acetylcholine which results in increases in acetylcholine. Is currently in preliminary trials for Alzheimer's.TS
Insufflated
Route dataTripSit
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| — | 50–75 µg | 75–150 µg | — | —+ |
| After-effects | 1–14 hours |
|---|
Mechanism of actionPH
Huperzine A has been found to be an inhibitor of the enzyme acetylcholinesterase. This is the same mechanism of action of pharmaceutical drugs such as [galantamine] and [donepezil] used to treat Alzheimer's disease.
PharmacodynamicsPH
Huperzine A is an alkaloid derived from <i>Huperzia serrata</i> (which is available as an herbal product in the US). It is under investigation as an acetylcholinesterase inhibitor. Clinical trials in China have shown that huperzine A is comparably effective to the drugs currently on the market, and may even be somewhat safer in terms of side effects.
External links
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.