Ibogaine
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| PsychonautWiki | TripSit | Pharmacology | TiHKAL | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | ≈ | ||
| Also known as | IbogaineEndabuseIboga | iboga | — | — | ≈ |
| Safety | |||||
| Addiction potential | not habit-forming | — | — | — | |
| Dose · Oral | |||||
| Common | 15–22 mg/kg of body weight | 16–22 mg | — | — | ≠ |
| Duration | |||||
| Onset | 30–180 minutes | 45–180 minutes | — | — | ≠ |
| Total | — | 24–30 hours | — | — | |
| After-effects | 24–72 hours | 24–72 hours | — | — | = |
| Pharmacology | |||||
| Receptor activity | — | — | Sigma intracellular receptor 2Neuronal acetylcholine receptor; alpha3/beta4Mu-type opioid receptorKappa-type opioid receptorUncheckedMuscarinic acetylcholine receptor M1Sigma non-opioid intracellular receptor 1 | — | |
| Half-life | — | — | To investigate the pharmacokinetic properties of ibogaine, a putatively anti-addictive alkaloid, levels of this drug were quantified in plasma and tissues for up to 3 hr following i.v. infusion in rats. Immediately following a 31-35 min infusion (20 mg/kg). ... The plasma time course in 5 of 7 animals demonstrated an excellent fit to a two-compartment pharmacokinetic model, with alpha and beta half-lives of 7.3 min and 3.3 hr, respectively. ... | — | |
Dose at a glance
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Duration at a glance
Total duration on one shared scale.
PsychonautWiki summary
Ibogaine can cause life-threatening heart complications.[1] It is strongly discouraged to use this substance in high doses or for multiple days in a row. Additionally, a trip sitter with proper medical training and equipment must be present. Please see this section for more details.
TripSit summary
An alkaloid found in many African plants most famously Iboga, with psychedelic and hallucinogenic properties. May be unpleasant. Traditionally used in tribal environments for coming-of-age rituals, it has recently been used as an alternative treatment for drug addiction although this usage has not been backed by conclusive data in humans. Has killed in overdose.
TiHKAL summary
A powerful and physically demanding psychoactive with deep cultural roots in the Bwiti religious rites of Gabon, where the iboga root bark serves as a sacrament, and a history of use in psychotherapy for surfacing and reliving early memories, as well as experimental use against heroin dependency. Reports describe it as a rough journey in both body and mind, marked by intense anxiety and apprehension, an unfamiliar mood, dark-only visual hallucinations (dancing blue disks), bodily sensory disturbances, and autonomic signs like dry mouth, sweating, and raised pulse.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.