Ketamine
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| PsychonautWiki | TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|---|
| Classification | ||||||
| Class / category | — | — | — | ≈ | ||
| Also known as | KetamineKKetKittySpecial KCat TranquilizerKetasetKetalarKetanestVitamin KPurpleJet | kketkittykittens | — | — | — | ≈ |
| Safety | ||||||
| Addiction potential | moderate to high abuse potential and produces psychological dependence with chronic use | — | — | — | — | |
| Dangerous interactions | — | — | — | ≈ | ||
| Dose · Insufflated | ||||||
| Threshold | 5 mg | 5 mg | — | — | — | = |
| Light | 10–30 mg | 20–50 mg | — | — | — | ≠ |
| Common | 30–75 mg | 50–125 mg | — | — | — | ≠ |
| Strong | 75–150 mg | 125–175 mg | — | — | — | ≠ |
| Heavy | 150 mg+ | 175 mg+ | — | — | — | ≠ |
| Dose · Oral | ||||||
| Threshold | 50 mg | — | — | — | — | |
| Light | 50–100 mg | — | — | — | — | |
| Common | 100–300 mg | — | — | — | — | |
| Strong | 300–450 mg | — | — | — | — | |
| Heavy | 450 mg+ | — | — | — | — | |
| Duration | ||||||
| Onset | 1–3 minutes | — | — | — | — | |
| Total | 1–2 hours | 1–2 hours | — | — | — | = |
| After-effects | 2–12 hours | 1–2 hours | — | — | — | ≠ |
| Pharmacology | ||||||
| Receptor activity | — | — | Glutamate [NMDA] receptorUncheckedGlutamate NMDA receptor; Grin1/Grin2aGlutamate NMDA receptor; Grin1/Grin2b | GRIN2DGRIA1CHRNA1Grin1 | — | ≠ |
| Half-life | — | — | The reported half-life in preclinical studies for ketamine is 186 min. ... The pharmacokinetics and distribution of ketamine and its biotransformation products in dogs after extradural administration of ketamine at L4-5 /were studied/. ... The elimination half-life values of the parent drug for both biological fluids were similar (4.3 (2.96) hr and 4.6 (3.31) hr for plasma and CSF, respectively). ... The half live is 2.5 hours in adults and 1 to 2 hours in children. beta phase half-life: 3 hours /From table/ ... Following intravenous administration, the ketamine concentration has an initial slope (alpha phase) lasting about 45 minutes with a half-life of 10 to 15 minutes. This first phase corresponds clinically to the anesthetic effect of the drug. The anesthetic action is terminated by a combination of redistribution from the CNS to slower equilibrating peripheral tissues and by hepatic biotransformation to metabolite I. This metabolite is about 1/3 as active as ketamine in reducing halothane requirements (MAC) of the rat. The later half-life of ketamine (beta phase) is 2.5 hours. For more Biological Half-Life (Complete) data for Ketamine (10 total), please visit the HSDB record page. | — | — | |
| Protein binding | — | — | The plasma protein binding of ketamine accounts for 53.5% of the administered dose. | — | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
PsychonautWiki insufflated
TripSit Insufflated
0218.75 mg
LightCommonStrongHeavy
Duration at a glance
Total duration on one shared scale.
PsychonautWiki
TripSit
TripSit summary
A short acting dissociative anaesthetic and hallucinogen commonly used in emergency medicine. It is the prototypical dissociative, and is widely used at sub-anesthetic doses recreationally. Small doses are comparable with alcohol, while larger doses are immobilising and lead to psychedelic experiences: the "K-Hole."
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.