Lorazepam
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How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
| PsychonautWiki | TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | ≈ | ||
| Also known as | LorazepamAtivanOrfidalLorsilan | ativan | — | — | ≈ |
| Safety | |||||
| Addiction potential | extremely physically and psychologically addictive | — | — | — | |
| Toxicity | low toxicitypotentially lethal when mixed with depressants like alcohol or opioids | — | — | — | |
| Dose · Oral | |||||
| Threshold | 0.1 mg | — | — | — | |
| Light | 0.25–0.5 mg | — | — | — | |
| Common | 0.5–1.5 mg | 1–2 mg | — | — | ≠ |
| Strong | 1.5–2 mg | 2–4 mg | — | — | ≠ |
| Heavy | 2 mg+ | — | — | — | |
| Dose · Intramuscular | |||||
| Light | — | 0.25–0.5 mg | — | — | |
| Common | — | 0.5–1 mg | — | — | |
| Strong | — | 1–2 mg | — | — | |
| Duration | |||||
| Onset | — | 5–30 minutes | — | — | |
| Total | 4–8 hours | 4–8 hours | — | — | = |
| After-effects | — | 1–12 hours | — | — | |
| Pharmacology | |||||
| Receptor activity | — | — | UncheckedFatty acid-binding protein, liver | GABRA1Fabp1 | ≠ |
| Half-life | — | — | When administered parentally, the registered half-life of lorazepam is of 14 hours. Following the administration of 1 mg of lorazepam in healthy adult male volunteers and using a multi-doses equation based on a one-compartment model, the average elimination half-life of lorazepam was estimated to be 11 hours and 8 hours for sublingual and oral doses respectively. The absorption half-life was calculated to be 55 minutes for oral doses and 15 minutes for sublingual doses. | — | |
| Protein binding | — | — | Reports indicate that 85% of lorazepam administered dose is protein bound. | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
Duration at a glance
Total duration on one shared scale.
PsychonautWiki summary
Fatal overdose may occur when benzodiazepines are combined with other depressants such as opiates, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
TripSit summary
An intermediate acting benzodiazepine commonly known as Ativan, commonly prescribed as an alternative to Xanax. Sedating, hypnotic and anxiolytic. Potential to induce amnesia and lowered inhibitions in overdose. Do not combine with other depressants.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.