Lormetazepam
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Collated from TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as noctamidTS
Relatively rare prescription benzodiazepine. Short acting with a short half life. Generally only seen in the Netherlands. Sedative, hypnotic and anxiolytic.TS
Oral
Route dataTripSit
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| — | 0.5–1 mg | 1–2 mg | 2–4 mg | —+ |
| Onset | 10–30 minutes |
|---|---|
| Total | 4–8 hours |
| After-effects | 1–24 hours |
Mechanism of actionPH
Lormetazepam, as a benzodiazepine, binds to the regulatory site between the α and γ subunits of γ-aminobutryic acid (GABA) A receptors with γ2 and α1, α2, α3, or α5 subunits. This facilitates the opening of the chloride channel allowing chloride ions to flow into the neuron resulting in hyperpolarization. Hyperpolarized neurons require greater simulation to reach their action potential threshold. The general inhibitory effect on neuronal depolarization produces the effects of lormetazepam.
PharmacodynamicsPH
Lormetazepam is a benzodiazepine which reduces central nervous system (CNS) activity. It produces anxiolytic, muscle relaxant, sedative and hypnotic effects. Because it is a short-acting benzodiapine, it does not produce significant sedation after waking.
Pharmacokinetics
Half-lifePH
The terminal phase half life is 11 h.
MetabolismPH
Metabolised to an inactive metabolite via glucuronide conjugation
Plan a dose of Lormetazepam
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