← hubDrugs

MDPV

Discover related
Class
Dose
Duration

3 sources

← All substances
🔗 MergedComparePsychonautWikiTripSitPharmacology

Collated from PsychonautWiki, TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.

Sections
EntactogenStimulantMdxxSubstituted cathinonesSubstituted pyrrolidinesResearch-chemicalHabit-formingPW

Also known as MDPV, Bath Salts, NRG-1PW

MDPV may cause psychosis, mania and addiction at a significantly higher rate than other stimulants. Due to its unusually long duration, extreme potency, and compulsive nature, it is strongly discouraged to abuse this substance in high doses, multiple days in a row, or in combination with other drugs known to increase the risk of psychosis. MDPV is one of several designer drugs that has been sold as "bath salt" both in the US and in Europe; In a four-year period between September 2009 and August 2013, the European Union (EU) reported a concerningly high number of MDPV-related deaths, reaching 99.[1]PW

Oral

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
2 mg4–8 mg8–14 mg14–25 mg25 mg+
031.25 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset15–30 minutes
Peak1–4 hours
Offset0.5–2 hours
Total2–7 hours
After-effects2–48 hours
OnsetCome-upPeakOffset

Insufflated

Route dataTripSit

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
1 mg2–5 mg5–11 mg10–20 mg—+
020 mg
LightCommonStrongHeavy
Duration
ShorterLonger
After-effects2–48 hours

Rectal

Route dataTripSit

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
1 mg3–8 mg6–12 mg10–25 mg—+
025 mg
LightCommonStrongHeavy
Duration
ShorterLonger
After-effects2–48 hours

Dangerous interactionsPW

25x-NBOMe25x-NBOHTramadolMAOIs

Unsafe interactionsPW

DXMMDMAStimulants

Caution / uncertainPW

AlcoholMXEDissociatives

Pharmacokinetics

MetabolismPH

The metabolism of methylenedioxypyrovalerone (MDPV) was evaluated in vitro using human liver microsomes and S9 cellular fractions for CYP450 phase I and uridine 5'-diphosphoglucuronosyltransferase (UGT) and sulfotransferase (SULT) phase II metabolism studies. The resulting metabolites were subsequently liquid/liquid extracted and analyzed using gas chromatography/mass spectrometry (GC/MS) as trimethylsilyl (TMS) derivatives. The structures of the metabolites were further confirmed by accurate mass measurement using a liquid chromatography/quadrupole time-of-flight (LC/QTOF) mass spectrometer. The studies demonstrated that the main metabolites of MDPV are catechol and methyl catechol pyrovalerone, which are in turn sulfated and glucuronated. ...

Plan when to take MDPV — see where onset, peak and comedown land on the clock

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.