Methylphenidate
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How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
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| PsychonautWiki | TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|---|
| Classification | ||||||
| Class / category | — | — | — | ≈ | ||
| Also known as | MethylphenidateConcertaMethylinRitalinEquasym XL | mphritalinconcertabiphentin | — | — | — | ≈ |
| Safety | ||||||
| Addiction potential | moderately addictive with a high potential for abuse | — | — | — | — | |
| Dangerous interactions | — | — | — | — | ||
| Unsafe interactions | — | — | — | — | ||
| Dose · Insufflated | ||||||
| Threshold | 1 mg | — | — | — | — | |
| Light | 2–10 mg | 5–15 mg | — | — | — | ≠ |
| Common | 10–30 mg | 15–40 mg | — | — | — | ≠ |
| Strong | 30–60 mg | 40–60 mg | — | — | — | ≠ |
| Heavy | 60 mg+ | 60 mg+ | — | — | — | = |
| Dose · Oral | ||||||
| Threshold | 5 mg | — | — | — | — | |
| Light | 10–20 mg | 20–40 mg | — | — | — | ≠ |
| Common | 20–40 mg | 40–60 mg | — | — | — | ≠ |
| Strong | 40–60 mg | 60–80 mg | — | — | — | ≠ |
| Heavy | 60 mg+ | 80 mg+ | — | — | — | ≠ |
| Duration | ||||||
| Onset | 5–20 minutes | — | — | — | — | |
| Total | 2–4 hours | — | — | — | — | |
| After-effects | 1–4 hours | 1–24 hours | — | — | — | ≠ |
| Pharmacology | ||||||
| Receptor activity | — | — | Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporterSodium-dependent serotonin transporter | SLC6A3SLC6A2ADRA2AADRA2BADRA2CSLC6A4 | — | ≠ |
| Half-life | — | — | Concerta: The half-life of methylphenidate in adults following oral administration of Concerta® was approximately 3.5 h. Biphentin: Methylphenidate is eliminated from plasma with a mean half-life of 2.4 hours in children and 2.1 hours in adults. Methylphenidate (immediate release): Methylphenidate is eliminated from the plasma with a mean half-life of 2.4 hours in children and 2.1 hours in adults. Methylphenidate ... is a racemate; /in plasma/ its more potent (+) enantimoer has a t(1/2) of approximately 6 hr, and the less potent (-) enantiomer has a t(1/2) of approximately 4 hr. Concentrations in the brain exceed those in plasma. The mean terminal half-life (t1/2) of methylphenidate following administration of 20 mg Methylphenidate HCl Oral Solution (t1/2 = 2.7 hours) is comparable to the mean terminal t1/2 following administration of Ritalin (methylphenidate hydrochloride immediate-release tablets) (t1/2 = 2.8h) in healthy adult volunteers. | — | — | |
| Protein binding | — | — | Concerta: In humans, 15 ± 5% of methylphenidate in the blood is bound to plasma proteins. Biphentin: In blood, methylphenidate and its metabolites are distributed between plasma (57%) and erythrocytes (43%). Methylphenidate and its metabolites exhibit low plasma protein binding (approximately 15%). Methylphenidate (immediate release): In blood, methylphenidate and its metabolites are distributed between plasma (57%) and erythrocytes (43%). Methylphenidate and its metabolites exhibit low plasma protein binding (approx. 15%). | — | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
PsychonautWiki insufflated
TripSit Insufflated
075 mg
LightCommonStrongHeavy
TripSit summary
A psychostimulant commonly used in the treatment of ADHD, narcolepsy and obesity, particularly in the EU instead of Adderall. Methylphenidate is also a 5HT1A receptor agonist. Sometimes prescribed off-label to help the withdrawals from cocaine and other stimulants.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.