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N-Acetylcysteine

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PsychonautWikiPharmacology
Classification
Class / category
Also known as
N-Acetylcysteine
Safety
Dose · Oral
Threshold100 mg
Light400–600 mg
Common600–1000 mg
Strong1000–1500 mg
Heavy1500 mg+
Duration
Onset20–60 minutes
Total3–6 hours
Pharmacology
Receptor activity
Solute carrier family 22 member 6
Half-lifeThe mean terminal half life of acetylcysteine in adults is 5.6 hours and in pre-term neonates is 11 hours. Following IV administration of acetylcysteine, mean elimination half lives of 5.6 and 11 hours have been reported in adults and in neonates, respectively. The mean elimination half life was increased by 80% in patients with severe liver damage (i.e., alcoholic cirrhosis (Child-Pugh score of 7-13) or primary and/or secondary biliary cirrhosis (Child-Pugh score of 5-11)).
Protein bindingAcetylcysteine is 66-97% protein bound in serum, usually to albumin.

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.