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O-Desmethyltramadol

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OpioidPhenylpropylamine

Also known as O-Desmethyltramadol

Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.

Addiction potential
moderately addictive with a high potential for abuse
Toxicity
moderate potential toxicity relative to its dose due to its potency; potentially lethal when mixed with depressants like alcohol or benzodiazepines
Tolerance
full tolerance develops with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerance
opioids

Intravenous

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
5 mg5–12.5 mg12.5–25 mg25–50 mg50 mg+
062.5 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset10–15 seconds
Peak2–5 hours
Offset2–4 hours
Total5–8 hours
After-effects1–3 Hours
OnsetCome-upPeakOffset

Oral

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
5 mg10–25 mg25–50 mg50–100 mg100 mg+
0125 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset20–40 minutes
Come-up30–40 minutes
Peak2–5 hours
Offset2–4 hours
Total6–10 hours
After-effects1–3 hours
OnsetCome-upPeakOffset

Sublingual

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
5 mg10–25 mg25–50 mg50–80 mg80 mg+
0100 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset20–40 minutes
Peak2–5 hours
Offset2–4 hours
Total5–10 hours
After-effects1–3 hours
OnsetCome-upPeakOffset

Caution / uncertain

MAOIsNitrousPCPStimulants
Plan when to take O-Desmethyltramadol — see where onset, peak and comedown land on the clock

Source: PsychonautWiki — O-Desmethyltramadol ↗

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.