Pagoclone
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An anxiolytic drug related to zopiclone with no sedative or hypnotic qualities. Has been investigated as a possible alcohol replacement. Related in structure and effect to Zopiclone and Zolpidem.TS
Mechanism of actionPH
Pagoclone is a subtype-selective drug which binds primarily to the alpha2/alpha3 subtypes of the GABAA receptor which are responsible for the anti-anxiety effects of these kind of drugs, but has relatively little efficacy at the alpha1 subtype which produces the sedative and memory loss effects.
PharmacodynamicsPH
Pagoclone was originally developed as an anti-anxiety drug, but never commercialised. It is a partial agonist acting at GABAA receptors in the brain. In contrast to zopiclone, pagoclone produces anxiolytic effects with little or no sedative or amnestic actions at low doses.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.