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Paracetamol

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Classification
Class / category
Also known as
acetaminophenparacetamoltylenol
Safety
Dose · Oral
Common200–500 mg
Duration
Onset60–60 minutes
Total4–6 hours
After-effects1–2 hours
Pharmacology
Receptor activity
Xaa-Pro dipeptidase
CNR1PTGS2TRPV1ALOX15ALOX5APCA1CA12Ca13CA14Ca15CA2CA3CA4CA7CA9MBNR1I3
Half-lifeThe half-life for adults is 2.5 h after an intravenous dose of 15 mg/kg. After an overdose, the half-life can range from 4 to 8 hours depending on the severity of injury to the liver, as it heavily metabolizes acetaminophen. The elimination half life is 1-3 hours after a therapeutic dose but may be greater than 12 hours after an overdose.
Protein bindingThe binding of acetaminophen to plasma proteins is low (ranging from 10% to 25%), when given at therapeutic doses.

TripSit summary

A common, over the counter, fever reducer and painkiller. It is mixed with many common opiates. Can cause liver damage and failure in higher doses. No recreational value.

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.