α-PVP
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2 sources
Collated from TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as alpha-pvp, apvp, alpha-Pyrrolidinopentiophenone, flocka, flakka, α-pvpTS
A potent, short-lasting pyrovalerone-type stimulant which became popular despite often being said to not be particularly euphoric, perhaps due to its propensity to cause compulsive redosing. Effects should be similar to MDPV.TS
Oral
Route dataTripSit
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| — | 5–10 mg | 10–25 mg | — | 25 mg+ |
031.25 mg
LightCommonStrongHeavy
| Onset | 5–15 minutes |
|---|---|
| Total | 2–5 hours |
| After-effects | 1–48 hours |
OnsetCome-upPeakOffset
🧬 Receptor activityPH
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| Cytochrome P450 1B1 | — | Ki 16 nM | CHEMBL | TargetCytochrome P450 1B1 Action— AffinityKi 16 nM SourceCHEMBL |
| Unchecked | — | Ki 17 nM | CHEMBL | TargetUnchecked Action— AffinityKi 17 nM SourceCHEMBL |
| Cytochrome P450 1A2 | — | Ki 20 nM | CHEMBL | TargetCytochrome P450 1A2 Action— AffinityKi 20 nM SourceCHEMBL |
| Aromatase | — | Ki 20 nM | CHEMBL | TargetAromatase Action— AffinityKi 20 nM SourceCHEMBL |
| Cytochrome P450 1A1 | — | Ki 45 nM | CHEMBL | TargetCytochrome P450 1A1 Action— AffinityKi 45 nM SourceCHEMBL |
| Adenosine receptor A1 | — | Ki 660.6 nM | CHEMBL | TargetAdenosine receptor A1 Action— AffinityKi 660.6 nM SourceCHEMBL |
| Adenosine receptor A2a | — | Ki 1320 nM | CHEMBL | TargetAdenosine receptor A2a Action— AffinityKi 1320 nM SourceCHEMBL |
| Substance-K receptor | — | Ki 1949 nM | CHEMBL | TargetSubstance-K receptor Action— AffinityKi 1949 nM SourceCHEMBL |
| Cytochrome P450 3A6 | — | Ki 80100 nM | CHEMBL | TargetCytochrome P450 3A6 Action— AffinityKi 80100 nM SourceCHEMBL |
Plan when to take α-PVP — see where onset, peak and comedown land on the clock
Plan a dose of α-PVP
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