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Rolicyclidine

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3 sources

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Collated from PsychonautWiki, TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.

Sections
DissociativeArylcyclohexylaminesResearch-chemicalHabit-formingTentativePW

Also known as PCPyPW

PCPy may cause psychosis and mania at a significantly higher rate than other dissociatives.[1][2] It is strongly discouraged to use this substance in high doses or multiple days in a row. Please see this section for more details.PW

Addiction potentialPW
highly addictive with a high potential for adverse side effects such as psychosis
TolerancePW
full tolerance with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerancePW
dissociative|dissociatives

Insufflated

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
1 mg2–4 mg4–8 mg8–15 mg—+
015 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset3–30 minutes
Come-up30–90 minutes
Peak2–3 hours
Offset1–2 hours
Total4–6 hours
After-effects4–48 hours
OnsetCome-upPeakOffset

Oral

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
1 mg3–5 mg5–9 mg9–13 mg—+
013 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset20–90 minutes
Come-up30–120 minutes
Peak2–3 hours
Offset3–4 hours
Total6–12 hours
After-effects12–48 hours
OnsetCome-upPeakOffset

Smoked

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
1 mg2–4 mg4–8 mg8–12 mg—+
012 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset2–20 minutes
Come-up20–40 minutes
Peak2–3 hours
Offset1–2 hours
Total4–6 hours
After-effects4–48 hours
OnsetCome-upPeakOffset

Caution / uncertainPW

MXECaffeine

Mechanism of actionPH

Rolicyclidine works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA Receptor.

PharmacodynamicsPH

Rolicyclidine is similar in effects to phencyclidine but is slightly less potent and has less stimulant effects. Instead it acts by inducing a sedative effect described as being somewhat similar to a barbiturate, but with additional PCP-like dissociative, anaesthetic and hallucinogenic effects.

Plan when to take Rolicyclidine — see where onset, peak and comedown land on the clock

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.