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| PsychonautWiki | Pharmacology | ||
|---|---|---|---|
| Classification | |||
| Safety | |||
| Duration | |||
| Pharmacology | |||
| Receptor activity | — | Cannabinoid receptor 1Cannabinoid receptor 2 | |
| Half-life | — | The elimination phase of dronabinol can be described using a two-compartment model with an initial (alpha) half-life of about 4 hours and a terminal (beta) half-life of 25 to 36 hours. The elimination phase of dronabinol can be described using a two compartment model with an initial (alpha) half-life of about 4 hours and a terminal (beta) half-life of 25 to 36 hours. After the pseudo-equilibrium is reached, THC is then slowly eliminated. This slow elimination is primarily due to the slow return of THC from sequestered tissues to blood. The terminal half-life of THC is approximately 1 day. /Several investigators have/ suggested terminal half-life /ranging between/ 19 to 36 hours. There are no significant differences in plasma profiles for chronic and infrequent users or in half-lives in moderate users before and after a 2-week exposure of THC. The elimination half-life of dronabinol (delta-1-tetrahydrocannabinol) in 3 chronic marihuana users following smoking 4 cigarettes over a 2 day period is reported. The elimination half-life in blood plasma was calculated to be 4.1 days (range 2.9-5.0 days). The terminal plasma half-life of metabolites from THC administration is approximately 50 hours, which is longer than that of THC. ... /Metabolites/ | |
| Protein binding | — | The plasma protein binding of dronabinol and its metabolites is approximately 97%. | |
PsychonautWiki summary
Summary sheet: Tetrahydrocannabinol Template:SubstanceBox/Tetrahydrocannabinol
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.