Thiopental
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| TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|
| Classification | ||||
| Class / category | — | — | ||
| Safety | ||||
| Duration | ||||
| After-effects | 1–24 hours | — | — | |
| Pharmacology | ||||
| Receptor activity | — | — | GABRA1Kcnc4Gabrp | |
| Half-life | — | 3-8 hours Following small iv doses of thiopental, the drug appears to decline in a monoexponential (first order) fashion, with an elimination half-life of about 3-22 hours. Following a rapid iv ('bolus") injection, pharmacokinetics of thiopental can be described by a triexponential equation; the drug appears to undergo a rapid and slow distribution phase followed by a terminal elimination phase. In the rapid distribution phase, thiopental equilibrates rapidly in highly perfused organs (CNS, viscera), while in the slow distribution phase the drug equilibrates between highly perfused organs and the adipose tissue. In adults, the mean plasma half-lives in the initial distribution phase and slow distribution phase are about 1.7-13.2 and 39.5-161.4 minutes, respectively. ... At high therapeutic concentrations, pharmacokinetics of thiopental can be characterized by Michaelis-Menten kinetics, with a first-order elimination half-life of 9.72-49.4 hours. In pediatric patients (5 months to 13 years of age), the elimination half-life of thiopental was about one-half the elimination half-life in adults (about six hours); however the elimination half-life in neonates was increased two-fold compared with their mothers (about 15 hours). | — | |
| Protein binding | — | Approximately 80% of the drug in the blood is bound to plasma protein. | — | |
TripSit summary
Barbiturate that kicks in very quickly, that is used to Anesthesia, Medical induced comas among other things.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.