Amphetamine
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| PsychonautWiki | TripSit | Pharmacology | DailyMed | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | ≈ | ||
| Also known as | AmphetamineSpeedAdderallPep | speedpeppamphetaminesamphetaminamfetamineamphheartspep | — | — | ≈ |
| Safety | |||||
| Addiction potential | has high abuse potential and can cause psychological dependence with chronic use | — | — | — | |
| Toxicity | exact toxic dosage is unknown | — | — | — | |
| Dangerous interactions | — | — | — | ||
| Unsafe interactions | — | — | — | ||
| Dose · Insufflated | |||||
| Threshold | 4 mg | — | — | — | |
| Light | 6–15 mg | 15–25 mg | — | — | ≠ |
| Common | 15–30 mg | 25–40 mg | — | — | ≠ |
| Strong | 30–50 mg | 40–75 mg | — | — | ≠ |
| Heavy | 50 mg+ | 75 mg+ | — | — | ≠ |
| Dose · Intravenous | |||||
| Threshold | 4 mg | — | — | — | |
| Light | 6–15 mg | — | — | — | |
| Common | 15–30 mg | — | — | — | |
| Strong | 30–50 mg | — | — | — | |
| Heavy | 50 mg+ | — | — | — | |
| Dose · Oral | |||||
| Threshold | 2.5 mg | — | — | — | |
| Light | 5–10 mg | 10–20 mg | — | — | ≠ |
| Common | 10–25 mg | 20–50 mg | — | — | ≠ |
| Strong | 25–50 mg | 50–70 mg | — | — | ≠ |
| Heavy | 50 mg+ | 70 mg+ | — | — | ≠ |
| Duration | |||||
| Onset | 1–5 minutes | — | — | — | |
| Total | 3–6 hours | — | — | — | |
| After-effects | 2–4 hours | 1–12 hours | — | — | ≠ |
| Pharmacology | |||||
| Receptor activity | — | — | Serotonin 1 (5-HT1) receptorSerotonin 2 (5-HT2) receptor5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2CSigma non-opioid intracellular receptor 1Phenylethanolamine N-methyltransferase | — | |
| Half-life | — | — | The half-life of amphetamine highly depends on the isomer. For d-amphetamine, the reported half-life is of approximately 9-11 hours while for l-amphetamine the half-life is reported to be of 11-14 hours. The urine pH can modify this pharmacokinetic parameter which can vary from 7 hours in acid urine to 34 hours for alkaline urine. Biological half-life is between 10-13 hr in adults and 9-11 hr in children. | — | |
| Protein binding | — | — | The reported protein binding of amphetamine is relatively low and register to be of 20%. | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
PsychonautWiki insufflated
TripSit Insufflated
093.75 mg
LightCommonStrongHeavy
TripSit summary
A very popular CNS stimulant available on prescription and black markets. Recreational in high doses, producing mild euphoria and an abundance of energy. Popular in eastern europe and the US.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.