Bromazepam
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Collated from PsychonautWiki, TripSit, Pharmacology, DrugCentral. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as Bromazepam, Brozam, Lectopam, Lexomil, Lexotan, Lexilium, Lexaurin, Brazepam, Rekotnil, Bromaze, Somalium, Lexatin, Calmepam, Zepam, LexotanilPW
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Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 1.5 mg | 1.5–3 mg | 3–6 mg | 6–12 mg | 12 mg+ |
| Onset | 14–15 minutes |
|---|---|
| Come-up | 15–120 minutes |
| Peak | 2–12 hours |
| Offset | 30–60 minutes |
| Total | 6–15 hours |
| After-effects | 12–22 hours |
Dangerous interactionsPW
🧬 Receptor activityDC
Mechanism of actionPH
Bromazepam binds to the GABA-A receptor producing a conformational change and potentiating its inhibitory effects. Other neurotransmitters are not influenced.
PharmacodynamicsPH
Bromazepam is a lipophilic, long-acting benzodiazepine and with sedative, hypnotic, anxiolytic and skeletal muscle relaxant properties. It does not possess any antidepressant qualities. Bromazepam, like other benzodiazepines, presents a risk of abuse, misuse, and dependence. According to many psychiatric experts, Bromazepam has a greater abuse potential than other benzodiazepines because of fast resorption and rapid onset of action.
Pharmacokinetics
Half-lifePH
10-20 hours
AbsorptionPH
Bioavailability is 84% following oral administration. The time to peak plasma level is 1 - 4 hours. Bromazepam is generally well absorbed after oral administration.
Urine (69%), as metabolites
1.56 L/kg
0.82 mL/min/kg.
MetabolismPH
Hepatically, via oxidative pathways (via an enzyme belonging to the Cytochrome P450 family of enzymes). One of the main metabolites is 3-hydroxybromazepam. It is pharmacologically active and the half life is similar to that of the parent compound.
Bromazepam has known human metabolites that include 3-Hydroxybromazepam.
Hepatically, via oxidative pathways (via an enzyme belonging to the Cytochrome P450 family of enzymes). One of the main metabolites is 3-hydroxybromazepam. It is pharmacologically active and the half life is similar to that of the parent compound.
Route of Elimination: Urine (69%), as metabolites
Half Life: 10-20 hours
Protein bindingPH
70%
Plan a dose of Bromazepam
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Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.