Clomethiazole
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| TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|
| Classification | ||||
| Class / category | — | — | ||
| Safety | ||||
| Dose · Oral | ||||
| Threshold | 100 mg | — | — | |
| Light | 100–150 mg | — | — | |
| Common | 150–200 mg | — | — | |
| Heavy | 200 mg+ | — | — | |
| Duration | ||||
| Onset | 15–40 minutes | — | — | |
| Total | 5–8 hours | — | — | |
| After-effects | 1–16 hours | — | — | |
| Pharmacology | ||||
| Receptor activity | — | — | GABRA1 | |
TripSit summary
Structurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute alcohol withdrawal.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.