Clomethiazole
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Structurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute alcohol withdrawal.
Oral
Route dataTripSit
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 100 mg | 100–150 mg | 150–200 mg | — | 200 mg+ |
0250 mg
LightCommonStrongHeavy
| Onset | 15–40 minutes |
|---|---|
| Total | 5–8 hours |
| After-effects | 1–16 hours |
OnsetCome-upPeakOffset
Plan when to take Clomethiazole — see where onset, peak and comedown land on the clock
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Source: TripSit — Clomethiazole ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.