Cyclobenzaprine
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| TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | — | ||
| Also known as | flexerilapo-cyclobenzaprinfexmidnovo-cycloprine | — | — | — | |
| Safety | |||||
| Dose · Oral | |||||
| Light | 2–5 mg | — | — | — | |
| Common | 5–10 mg | — | — | — | |
| Strong | 10–15 mg | — | — | — | |
| Heavy | 15 mg+ | — | — | — | |
| Duration | |||||
| Onset | 15–45 minutes | — | — | — | |
| Total | 6–12 hours | — | — | — | |
| After-effects | 1–6 hours | — | — | — | |
| Pharmacology | |||||
| Receptor activity | — | — | HTR2AHTR2CHTR2BHTR6HTR7AOX1HRH1ABCB1CHRM1CHRM2CHRM3RETSLC6A2SLC6A4 | — | |
| Half-life | — | The effective half-life of cyclobenzaprine in young healthy subjects is approximately 18 hours. These values are extended in the elderly and those with hepatic insufficiency, with a mean effective half-life of 33.4 hours and 46.2 hours in these groups, respectively. Cyclobenzaprine is eliminated quite slowly, with an effective half-life of 18 hours (range 8-37 hours; n=18) ... . | — | — | |
| Protein binding | — | Cyclobenzaprine is approximately 93% protein bound in plasma. It has been identified as specifically having a high affinity for human serum albumin. | — | — | |
TripSit summary
Muscle relaxant and CNS depressant used to relieve skeletal muscle spasms and associated pain in acute musculoskeletal conditions. Sometimes prescribed off-label for treatment of fibromyalgia or as a sleep aid. Has little recreational value alone, but may potentiate some opioids. May cause drowsiness, dry mouth and dizziness.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.