Dextromethorphan
Discover related
4 sources
🧬 Receptor activity
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2C (GRIN2C) | Blocker | 6.33 IC50 | DRUGCENTRAL | TargetGlutamate receptor ionotropic, NMDA 2C (GRIN2C) ActionBlocker Affinity6.33 IC50 SourceDRUGCENTRAL |
| Glutamate receptor ionotropic, NMDA 3A (GRIN3A) | Antagonist | 5.699 IC50 | DRUGCENTRAL | TargetGlutamate receptor ionotropic, NMDA 3A (GRIN3A) ActionAntagonist Affinity5.699 IC50 SourceDRUGCENTRAL |
| Sigma non-opioid intracellular receptor 1 (SIGMAR1) | Agonist | 6.458 D2 | DRUGCENTRAL | TargetSigma non-opioid intracellular receptor 1 (SIGMAR1) ActionAgonist Affinity6.458 D2 SourceDRUGCENTRAL |
| Cytochrome P450 2D6 (CYP2D6) | — | 4.48 Ks | DRUGCENTRAL | TargetCytochrome P450 2D6 (CYP2D6) Action— Affinity4.48 Ks SourceDRUGCENTRAL |
| Glutamate NMDA receptor (Grin1) | — | 5.65 Ki | DRUGCENTRAL | TargetGlutamate NMDA receptor (Grin1) Action— Affinity5.65 Ki SourceDRUGCENTRAL |
| Sigma non-opioid intracellular receptor 1 (Sigmar1) | — | 5.29 Ki | DRUGCENTRAL | TargetSigma non-opioid intracellular receptor 1 (Sigmar1) Action— Affinity5.29 Ki SourceDRUGCENTRAL |
| Sodium channel alpha subunits; brain (Types I, II, III) (Scn1a) | — | 5.89 IC50 | DRUGCENTRAL | TargetSodium channel alpha subunits; brain (Types I, II, III) (Scn1a) Action— Affinity5.89 IC50 SourceDRUGCENTRAL |
| Sodium-dependent serotonin transporter (SLC6A4) | — | 8.842 Ki | DRUGCENTRAL | TargetSodium-dependent serotonin transporter (SLC6A4) Action— Affinity8.842 Ki SourceDRUGCENTRAL |
| Solute carrier family 22 member 1 (SLC22A1) | — | 4.98 IC50 | DRUGCENTRAL | TargetSolute carrier family 22 member 1 (SLC22A1) Action— Affinity4.98 IC50 SourceDRUGCENTRAL |
| Taste receptor type 2 member 46 (TAS2R46) | — | 4.51 EC50 | DRUGCENTRAL | TargetTaste receptor type 2 member 46 (TAS2R46) Action— Affinity4.51 EC50 SourceDRUGCENTRAL |
External links
PubChem 5360696 ↗CAS 125-71-3 ↗KEGG C06947 ↗ChEBI CHEBI:4470 ↗ChEBI CHEBI:92579 ↗ChEMBL CHEMBL52440 ↗KEGG D03742 ↗DrugBank DB00514 ↗ChemSpider ↗ChEBI/ChEMBL ↗ChEBI/ChEMBL ↗Guide to Pharmacology ↗NIH ↗NIH ↗DrugBank ↗ChEBI/ChEMBL ↗NIH ↗CAS 125-69-9 ↗CAS 125-70-2 ↗PsychonautWiki ↗Erowid ↗Experience reports (PiHKAL) ↗Experience reports (TiHKAL) ↗
Source: DrugCentral — Dextromethorphan ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.