Diclofensine
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2 sources
Collated from TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as ro8-4650TS
A triple monoamine reuptake inhibitor developed by Hoffman-LaRoche in the 1970s as an antidepressant but discontinued, probably due to high abuse potential. Has not become popular as a recreational drug at this time. Acts as an SNDRI, mostly inhibits dopamine and noradrenaline.TS
Oral
Route dataTripSit
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 12 mg | 30–40 mg | 40–60 mg | — | 60 mg+ |
075 mg
LightCommonStrongHeavy
| Total | 4–6 hours |
|---|
🧬 Receptor activityPH
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter | — | Ki 8.8 nM | CHEMBL | TargetSodium-dependent noradrenaline transporter Action— AffinityKi 8.8 nM SourceCHEMBL |
| Sodium-dependent serotonin transporter | — | Ki 10.3 nM | CHEMBL | TargetSodium-dependent serotonin transporter Action— AffinityKi 10.3 nM SourceCHEMBL |
| Sodium-dependent dopamine transporter | — | Ki 10.9 nM | CHEMBL | TargetSodium-dependent dopamine transporter Action— AffinityKi 10.9 nM SourceCHEMBL |
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