DOI
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4 sources
Collated from PsychonautWiki, TripSit, Pharmacology, PiHKAL. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as DOI, 2,5-DIMETHOXY-4-IODOAMPHETAMINEPW
A potent, long-acting psychedelic stimulant. Historically, it has rarely been consumed deliberately, but occasionally sold as LSD. However, it has recently found its own little nest in the research chemical community.TS
Addiction potentialPW
not habit-forming
ToxicityPW
toxic dose is unknown
TolerancePW
full tolerance almost immediately after ingestion; half after 5-7 days; baseline after 10-14 days
Cross-tolerancePW
psychedelic
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 0.5 mg | 0.5–1 mg | 1–2 mg | 2–3 mg | 3 mg+ |
03.75 mg
LightCommonStrongHeavy
| Onset | 1–2 hours |
|---|---|
| Come-up | 1.5–3 hours |
| Total | 16–24 hours |
OnsetCome-upPeakOffset
Dangerous interactionsPW
Unsafe interactionsPW
Caution / uncertainPW
🧬 Receptor activityPH
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | — | Ki 0.28 nM | CHEMBL | Target5-hydroxytryptamine receptor 2A Action— AffinityKi 0.28 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2C | — | Ki 0.48 nM | CHEMBL | Target5-hydroxytryptamine receptor 2C Action— AffinityKi 0.48 nM SourceCHEMBL |
| Serotonin receptor 2a and 2c (5HT2A and 5HT2C) | — | Ki 0.7 nM | CHEMBL | TargetSerotonin receptor 2a and 2c (5HT2A and 5HT2C) Action— AffinityKi 0.7 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2B | — | Ki 0.75 nM | CHEMBL | Target5-hydroxytryptamine receptor 2B Action— AffinityKi 0.75 nM SourceCHEMBL |
| Serotonin 2 (5-HT2) receptor | — | Ki 19 nM | CHEMBL | TargetSerotonin 2 (5-HT2) receptor Action— AffinityKi 19 nM SourceCHEMBL |
| Serotonin 1 (5-HT1) receptor | — | Ki 920 nM | CHEMBL | TargetSerotonin 1 (5-HT1) receptor Action— AffinityKi 920 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 5A | — | Ki 1000 nM | CHEMBL | Target5-hydroxytryptamine receptor 5A Action— AffinityKi 1000 nM SourceCHEMBL |
Plan when to take DOI — see where onset, peak and comedown land on the clock
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External links
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.