Efavirenz
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| PsychonautWiki | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | — | ||
| Also known as | EfavirenzSustiva | — | — | — | |
| Safety | |||||
| Addiction potential | not known to be habit-forming | — | — | — | |
| Toxicity | low toxicitymay cause liver toxicity at high doses or after chronic use | — | — | — | |
| Dangerous interactions | — | — | — | ||
| Dose · Smoked | |||||
| Common | 600–1800 mg | — | — | — | |
| Duration | |||||
| Onset | 1–5 minutes | — | — | — | |
| After-effects | 6–12 hours | — | — | — | |
| Pharmacology | |||||
| Receptor activity | — | Human immunodeficiency virus type 1 reverse transcriptaseUnchecked | CYP3A4gag-polpolNR1I2reverse transcriptasreverse transcriptase | — | ≠ |
| Half-life | — | 40-55 hours The terminal elimination half-life of efavirenz is prolonged in patients with chronic liver disease. Following oral administration of a single 400-mg dose of efavirenz, an elimination half-life of 152 or 118 hours was reported in individuals with or without chronic liver disease, respectively. The terminal elimination half-life of efavirenz reported in single-dose studies is longer than that reported in multiple-dose studies and has averaged 52-76 hours after a single oral dose and 40-55 hours following administration of 200-400 mg daily for 10 days. | — | — | |
| Protein binding | — | 99.5-99.75% | — | — | |
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.