Escaline
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3 sources
Collated from PsychonautWiki, TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as EscalinePW
First synthesised in the 50s, this uncommon drug was reexamined by David Nichols in the 1990s. It is an analogue of mescaline which is roughly six times more potent, and is thus a powerful psychedelic phenethylamine. Subjective effects may include stimulation and hallucinations.TS
Addiction potentialPW
not habit-forming
ToxicityPW
toxic dose is unknown
TolerancePW
full tolerance almost immediately after ingestion; half after 3 days; baseline after 7 days
Cross-tolerancePW
psychedelic
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 20 mg | 30–50 mg | 50–100 mg | 100–150 mg | 150 mg+ |
0187.5 mg
LightCommonStrongHeavy
| Onset | 90–120 minutes |
|---|---|
| Total | 8–12 hours |
| After-effects | 3–5 hours |
OnsetCome-upPeakOffset
Dangerous interactionsPW
Unsafe interactionsPW
Caution / uncertainPW
🧬 Receptor activityPH
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | — | Ki 177.2 nM | CHEMBL | Target5-hydroxytryptamine receptor 2C Action— AffinityKi 177.2 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2A | — | Ki 215.6 nM | CHEMBL | Target5-hydroxytryptamine receptor 2A Action— AffinityKi 215.6 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2B | — | Ki 555.1 nM | CHEMBL | Target5-hydroxytryptamine receptor 2B Action— AffinityKi 555.1 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1A | — | Ki 6900 nM | CHEMBL | Target5-hydroxytryptamine receptor 1A Action— AffinityKi 6900 nM SourceCHEMBL |
Plan when to take Escaline — see where onset, peak and comedown land on the clock
Plan a dose of Escaline
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Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.