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Also known as Fentanyl, fentanil, Sublimaze, Actiq, Durogesic, Duragesic, Fentora, Matrifen, Haldid, Onsolis, Instanyl, Abstral, Lazanda

This substance is extraordinarily potent (i.e. active in the microgram range). For this reason, it should be handled with extreme care and never be eyeballed. Fentanyl can also be fatal when combined with depressants such as opiates, benzodiazepines, barbiturates, gabapentinoids, thienodiazepines or other GABAergic substances.[1] It is strongly encouraged to wear gloves while handling, use volumetric dosing combined with a milligram scale, and to not consume either moderate or heavy dosages of other depressants in combination with this drug.

Addiction potential
extremely addictive with a high potential for abuse
Toxicity
potentially fatal at heavy dosages; potentially lethal when mixed with depressants like alcohol or benzodiazepines; unintentionally transporting the substance from the skin by touching the mouth, nose or eyes is dangerous
Tolerance
full tolerance develops with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerance
opioids

Insufflated

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
5 μg10–25 μg25–50 μg50–75 μg—+
075 μg
LightCommonStrongHeavy
Onset15–30 minutes
Total1–4 hours
OnsetCome-upPeakOffset

Sublingual

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
5 μg10–25 μg25–50 μg50–75 μg75 μg+
093.75 μg
LightCommonStrongHeavy
Onset15–30 minutes
Total1–4 hours
OnsetCome-upPeakOffset

Transdermal

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
5 μg12–25 μg25–50 μg50–100 μg100 μg+
0125 μg
LightCommonStrongHeavy
Onset2–4 hours
Total48–72 hours
OnsetCome-upPeakOffset

Caution / uncertain

Plan when to take Fentanyl — see where onset, peak and comedown land on the clock

Source: PsychonautWiki — Fentanyl ↗

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.